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ATCC
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ATCC
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Journal: JAC-Antimicrobial Resistance
Article Title: Genetic and clinical landscape of methicillin-resistant Staphylococcus aureus isolates lacking the mec gene, in Japan
doi: 10.1093/jacamr/dlag008
Figure Lengend Snippet: A single-nucleotide polymorphism-based phylogenetic tree of methicillin resistance-lacking mec (MRLM) strains of Staphylococcus aureus . The whole genome sequences of all 13 strains analysed in this study (in red) were examined alongside those of 150 published MRLM strains, , downloaded from the NCBI database. The following MSSA genome sequences were also included: seven reference strains ATCC 25923 (ST243/CC30, CP009361.1), ATCC 29213 (ST5, GCA_001267715.2), ATCC 12600 (ST8, GCA_006094915.1), ATCC 9144 (ST30, GCA_900457695.1), NCTC 8325 (ST8, GCA_000013425.1), MSSA476 (ST1, GCA_000011525.1) and MSSA6850 (ST50, GCA_000462955.1), and eight previously reported clinical MSSA strains 10-00598 (ST22, GCA_028076695.1), 15-02736 (ST291, GCA_028082935.1), 16-01080 (ST45, GCA_028080235.1), 16-02665 (ST25, GCA_028075835.1), 18-01695 (ST398, GCA_028081975.1), 18-01787 (ST5, GCA_028081295.1), 19-00515 (ST15, GCA_028081935.1), and C00012754 (ST20, ERR418969). , Sequence types (STs) (inner ring), clonal complexes (CCs) (middle ring) and spa types (outer ring) are annotated. The tree scale indicates the number of substitutions per genome.
Article Snippet: A comparative analysis of the nucleotide sequences or deduced amino acid sequences extracted from 13 MRLMs with those from the
Techniques: Sequencing
Journal: bioRxiv
Article Title: BAY 11-7082 potentiates select β-lactams to inhibit growth of methicillin-resistant Staphylococcus aureus
doi: 10.64898/2026.01.13.699313
Figure Lengend Snippet: A. MRSA expresses five PBPs, PBP1, PBP2, PBP2A (pink), PBP3, and PBP4. B. FICI values calculated based on MRSA USA300 grown in the presence of BAY 11-7082 and another antibiotic. FICI values <0.5 represent synergy, values between 0.5-4 represent no interaction, and values >4 represent antagonism. C. FICI values for MRSA USA300 (pink) and MSSA ATCC 29213 (blue) grown in the presence of BAY 11-7082 and a β-lactam that synergizes with BAY 11-7082 in MRSA. Data represent an average of three independent experiments performed in triplicate.
Article Snippet: We conducted checkerboard assays with MRSA strain USA300, which has mecA ( , Figure S2 ), as well as methicillin-sensitive
Techniques: